The city's urgent care centre which treats hundreds of people each day has moved.
Yesterday morning it re-opened at a new location at the Balmoral building reception at Leicester's Royal Infirmary.
The change is part of a £40 million scheme to revolutionise the way urgent and emergency treatment is provided for the more than 160,000 patients who use the department each year.
The move will enable a start on the new Emergency Department.
Professor Azhar Farooqi, chair of Leicester City Clinical Commissioning Group, said: "The urgent care centre has been moved to the opposite side of the ambulance bay within the Balmoral building at Leicester's Royal Infirmary.
"The move is part of a bigger project which will make way for the development of new A&E services at the hospital."
The LRI's urgent care centre is available 24 hours a day, 365 days a year for people with minor injuries and illnesses.
Prof Farooqi, who is a GP, added: "Historically, we know there are capacity issues at the hospital's emergency department, and this is just the start of plans to ensure that the right changes are made and that these changes meet the demands and needs of patients and people that use the service."
Ben Teasdale, head of service for the emergency department at Leicester's Hospitals, said: "We are really pleased to be progressing our £40 million emergency floor development."
He said new signs and staff members would help redirect patients from the old location to the new one.
He added: "We very much hope visitors won't feel inconvenienced by the move and apologise if this is the case. But would like to reassure the public we have meticulously planned this move to ensure their care is not disrupted.
"This move, along with the exciting development of our much needed emergency floor, is absolutely the right thing for our patients."
Patients visiting the centre are first assessed by a nurse to make sure they receive their treatment in the most appropriate place for their condition. This could be at the centre, A&E, their own GP, or pharmacist.
The new urgent care centre is nearer to the patient drop-off point and any visitors waiting to be picked-up will now be sheltered.
The centre now has direct and quicker access to resuscitation and our assessment bay.
Local health bosses are planning to meet to help resolve existing capacity problems at the country's busiest single site A&E department.
A spokeswoman for the LRI said no date had been fixed for the meeting.
