Patients are facing their second battle in two years to keep their specialist clinic.
The Oadby and Wigston Leg Club has been providing social and clinical support for people with leg problems such as ulcers and blood circulation for seven years.
But now the Leicestershire Partnership NHS Trust, which pays for the nurses, wants to move clinical care away from the club which meets every Tuesday in the United Reformed Church Hall in Oadby.
Two years ago the trust apologised when a notice saying the club was to close was posted.
Officials said it had happened "in error" but that a new venue was being sought.
Ben Schelts, from Wigston and a regular at the club, said: "This seems to be just another attempt by the trust to close the club.
"We were told we can carry on as a social club but that people like myself with leg ulcers will have to go various surgeries for dressings and so on - it is an insult.
"From past experience when this happens there isn't always a qualified nurse available to see you."
He added: "As well as getting help and treatment from the nurses at the club I have made some cracking friends.
"We won't let the club go without a fight."
The club, which is attended by about 30 people each week, is accredited to the Lindsay Leg Club Foundation - a national charity.
Andrew Kingsley, a tissue viability nurse and lead infection control nurse at the Northern Eastern and Western Devon clinical commissioning group, is also infection control lead for the foundation.
He said: "It is possible to provide good clinical care safely in a setting such as the Oadby and Wigston Leg Club."
A spokesman for the Leicestershire Partnership NHS Trust said it was not looking to close the club just to move the clinical care.
He added: "The clinical aspect of the care will be provided by the same experienced team but carried out in a local health clinic, which meets the safe clinical guidelines we are required to follow.
"This new arrangement will allow leg club members to make appointments and for all clinical elements of the care to be provided, a service not currently available under the existing arrangements."
The spokesman said the changes were needed following recently quality reviews.
But he added: "We will continue to support the social model of care at the leg club sessions in Oadby and a nurse will continue to be available each week to provide health and wellbeing advice to members attending the club.
" We hope to be able to announce the location of where the clinical care will be provided very soon and to have the new arrangements in place early in 2015."
Health campaigner Zuffar Haq, a member of the Leicester Mercury Patients' Panel, fought to keep the club two years ago.
He said: "I met with trust officials and it was agreed to keep the club going.
"It is a unique facility and needs to be retained. Not only is it helping patients, but it is a great example of providing medical services in the community which patients value."
