Scrum-half Ben Youngs is the only Leicester Tigers player named in the England squad for the forthcoming autumn internationals against New Zealand, South Africa, Samoa and Australia.
That comes as little surprise with the likes of Tom Youngs, Ed Slater, Geoff Parling, Dan Cole and Tom Croft all currently on the injured list, while Manu Tuilagi misses out after picking up a groin injury against Ulster last weekend.
Harlequins' Danny Care and Northampton's Lee Dickson are also named at scrum-half in a 33-strong squad.
Youngs has won 38 caps so far and joins up with the England squad after Saturday's European Rugby Champions Cup match against Scarlets in Llanelli.
Tuilagi is replaced by Bath Rugby's Jonathan Joseph.
"There are a number of players unavailable for this series because of long term injury but they are all on the road to recovery and as always, it gives the opportunity for others to come in and stake their claim," said England head coach Stuart Lancaster.
"We have included Jonathan Joseph as an injury replacement for Manu. It is obviously disappointing to lose Manu but JJ has been in great form and deserves this chance.
"Our medics will continue to work closely with Leicester's and ensure that Manu is supported in his rehabilitation from his injury."
The squad includes lock George Kruis (Saracens) and winger Semesa Rokoduguni (Bath) for the first time, and will be captained by 'Quins back rower Chris Robshaw.