Leicester Tigers make nine changes from the side that defeated the Maori All Blacks on Tuesday in a bid to get their defence of the LV= Cup up and running.
Rob Hawkins and captain Brett Deacon return to the starting line-up following injury, while Mathew Tait makes his second successive start at full-back after 13 months on the sidelines.
Scrum-half Micky Young starts for the first time at Welford Road this season, and Dan Bowden returns to the back-line against his former club.
Andy Forsyth and Alex Lewington are brought in on the wings while Rob Andrew comes in at lock. Michael Noone, Richard Thorpe and Deacon make up the back row.
2 min: PENALTY (0-3) Irish get their second penalty in 150 seconds near the left-hand touch-line, just inside Tigers' 22. Ian Humphreys coolly slots his kick between the posts.
8 min: TRY (0-8) Tigers give the ball away in the Irish half and Sailosi Tagicakibau breaks down the right and off-loads inside to Anthony Watson, who dives over the line. Humphreys puts his conversion attempt wide.
13 min: A lovely pass out to the right by Bowden puts Rob Hawkins through. He off-loads to Noone, who gets over the line, but the pass is forward.
15 min: George Ford has the chance to get Tigers' points tally underway with a penalty just inside the visitors' half straight in front of the posts. But he skews his kick wide.
19 min: TRY (7-8) Matt Smith charges down a kick from Watson and the ball goes out of play on the Irish 5m line. From the line-out, Ed Slater picks it up and off-loads to Noone, who moves it to Andrew, who dives under the posts for Tigers' first points. Ford converts.
22 min: PENALTY (10-8) Irish are penalised for pushing in the line-out and Ford has a kick on the 10m line. He strikes it as clean as a whistle and it flies between the posts to give Tigers the lead for the first time.
38 min: PENALTY (13-8) Tagicakibau is penalised for holding on and Tigers have a penalty from about the same spot which Ford shanked earlier in the half. The youngster makes no mistake this time.
H-T: Tigers 13 London Irish 8
48 min: PENALTY (16-8) Irish are down to 14 men as Shane Geraghty is yellow-carded for a professional foul at the breakdown. Ford has a kick in front of the posts to get the second-half scoring under way. He takes his time and slots it home.
56 min: PENALTY (19-8) A dominant Tigers scrum forces the Irish pack to stand up and the hosts are awarded a penalty just inside the Irish half. Ford opts to go for the points and there is a huge roar as the fans see it sail between the posts.
65 min RED CARD: It's down to 14-a-side now as Boris Stankovich is shown a red card for a high tackle in midfield. It appeared that scrum-half Darren Allison slipped as he was about to be tackled.
69 min: TRY (19-15) Irish have an abundance of players on the overlap on the left-hand side. It is spun straight out to replacement wing Tom Homer, who dives right into the corner. Humphrey is successful with the conversion and there are only four points between the sides.
76 min: PENALTY (22-15) After a long period of attacking pressure from Tigers, they force the mistake and are awarded a penalty just outside the 22 straight in front of the posts. Ford takes his time while the crowd quieten down before successfully extending his side's lead.
F-T: Tigers 22 London Irish 15