Leicester Tigers will have to overcome some major obstacles tonight if they are to earn the right to defend their Aviva Premiership title.
Tigers are the underdogs as hosts and bitter rivals Northampton Saints have home advantage at Franklin's Gardens (7.45).
Saints are also the bookies' big favourites and have almost no injury worries going into the highly-anticipated clash.
Richard Cockerill's visitors, however, have been struck by injuries again, with the likes of key men Geoff Parling (concussion) and Ant Allen (knee) ruled out.
Blaine Scully, Rob Hawkins and Boris Stankovich also miss out, along with long-term absentees Dan Cole, Miles Benjamin and Tom Croft.
Tigers will also be aiming to become only the fourth side that has won an away Premiership semi-final.
Tigers have never failed to reach Twickenham during the last nine years and director of rugby Cockerill hopes to maintain that "ritual" again in a fortnight's time.
"The expectation here is great," he said. "I know players and supporters who have been here for almost a decade and all they know is winning a championship or getting to the final.
"That expectation is there. When most other clubs get to the final, it is a once-in-a-lifetime opportunity for players, coaches and supporters.
"But it has become a ritual for us. As a coach, I have never not been to a grand final.
"We have had plenty of injuries this season but, if I am being honest, I won't take much consolation if we have lost in a semi and people tell us that we were unlucky and whatever.
"Now we have made the last four, we want to try to win it, and they are the standards we want to have."
Despite Allen and Parling missing the game, Tigers have recalled a host of big-name players to the squad and Toby Flood takes over from Owen Williams at fly-half.
Saints have few injury concerns, with just hooker Dylan Hartley missing out of their first-choice XV.
"Saints are a good side and Mike Haywood has come in and done well for Hartley while he has been out," said Cockerill.
"It all adds up to a good contest. It will be fierce and fiery, no doubt.
"We know it is all or nothing for us. There is nothing for us on Monday morning if we don't get it right."
