Leicester Tigers hooker Tom Youngs will make his England debut tomorrow against Fiji at Twickenham in a squad that also includes brother Ben.
It will be the first time siblings have been included in the same England squad since Steffon and Delon Armitage in 2009.
It means the Youngs brothers will be among 20 key players missing for Tigers' opening match in defence of their LV= Cup trophy against Saracens at Welford Road tonight (7.45).
But for Tom, his England inclusion marks an incredible turnaround from centre to hooker, which began three years ago.
He has started only 18 games for Leicester but will be lining up to make his full England debut after gaining midweek experience on the summer tour of South Africa.
England head coach Stuart Lancaster said Youngs' inclusion was the result of lots of hard work on his game.
"Congratulations to Tom Youngs, who has made a great transition from centre to hooker in a short period," he said. "He deserves his chance."
Youngs is one of six Tigers in the team, along with prop Dan Cole, lock Geoff Parling, back-row Thomas Waldrom, fly-half Toby Flood and centre Manu Tuilagi. Brother Ben is on the bench.
Tigers team-mate Vereniki Goneva is on the wing for Fiji.