Government lawyers have met their counterparts in Portugal to discuss new leads in the case of Madeleine McCann.
London's chief crown prosecutor, Alison Saunders, and her deputy, Jenny Hopkins, flew to Portugal with Scotland Yard detectives in connection with the force's review of the case.
Madeleine, who was then nearly four, disappeared from her family's holiday apartment in Praia da Luz, Algarve, on May 3, 2007.
She vanished as her parents Kate and Gerry, of Rothley, dined at a nearby tapas restaurant with friends.
A Crown Prosecution Service (CPS) spokesman said: "Prosecutors from CPS London, and investigators from the Metropolitan Police Service visited their Portuguese counterparts on April 17 and 18 to discuss possible next steps in relation to the disappearance of Madeleine McCann."
Operation Grange, conducted by Scotland Yard's Homicide and Serious Crime Command, was launched in May 2011.
Last month, Detective Chief Superintendent Hamish Campbell said the review had identified ''both investigative and forensic opportunities" and had identified "more than a handful of people of interest".
As they marked the sixth anniversary of Madeleine's disappearance last month, Mr and Mrs McCann said they were encouraged by Operation Grange.
They said police seemed "more determined than ever".
