One of the city's two branches of leading book shop Waterstone's is to close.
The Market Street store, which used to be Dillon's until the merger of the two companies, will close its doors on June 1.
The shop employs nine staff, who are currently undergoing consultation over the planned closure.
The company says staff will be relocated where possible at one of its other stores in the region.
In a statement a spokeswoman said: "Waterstone's can confirm that its bookshop on Market Street in Leicester will cease trading on Saturday 1st June.
"Waterstone's employs nine people at Leicester Market Street. Staff are currently in consultation and will be relocated where possible."
She added: "We would like to thank the booksellers at our Market Street shop for their hard work and professionalism, and the shop's many customers for their loyal and friendly support and custom over the years.
"We hope to continue to serve them from our branch in Highcross Shopping Centre in Leicester, which is unaffected."
She added that the company was looking at a number of towns and cities where it has two or more shops.
She added: "The book market is challenging at the moment and in cities and towns where there are two or more shops where leases come up we are looking at on a case-by-case basis."
Former employee at the Market Street shop Stephen Naish, who now lives and works in Canada, said:"This means another vital high street store will be gone. This is one of many closures Waterstones has implemented over the past few months.
" I feel that the people who work at the store and those that frequently used the store should receive a fitting tribute.
"This is a great loss to Leicester's high street and also to the book industry as a whole."
