Politicians, business leaders and charity representatives will meet to discuss ways of tackling child poverty.
The city's Child Poverty Commission will hold its second annual conference in May.
About 200 people from public sector, voluntary and community organisations and the private sector attended the commission's inaugural conference held at De Montfort University last year.
This year's event will invite delegates to discuss what can be done in communities to help protect children from the worst impacts of poverty against a background of rising living costs and national welfare reforms.
There are 26,000 children from families in poverty in the city, according to the Government's definition of their income being less than 60 per cent of the national median income.
That is about £357 a week for a couple with two children.
Deputy city mayor and chairman of the Leicester Child Poverty Commission councillor Rory Palmer said: "It is vital that we continue to discuss the challenges around child poverty and work together to find ways to protect children from its worst impact.
"I am confident that our next conference will help shape practical action in our communities that will help tackle child poverty and the devastating impact it can have on people's lives."
The conference will take place at St Martin's House, near Leicester Cathedral, on May 17.
The Bishop of Leicester, the Rt Rev Tim Stevens, said: "The Diocese of Leicester and I feel St Martins House is a very appropriate venue for an event discussing issues around child poverty and how a city like Leicester can help combat this growing issue.
"We look forward to the positive actions that will come from the conference and to establishing closer links with the work of the Leicester Child Poverty Commission."