One lane of the southbound M1 will remain closed for some time following a collision involving a minibus.
The silver people carrier overturned at the exit for Misterton works area on the southbound carriageway near junction 20 at about 10am.
Air Ambulance crews were called to help two people who were trapped in the vehicle.
They have been taken to hospital.
Their condition is not known.
A police spokeswoman said that the outer two lanes of the motorway were now open.
However, the inside lane is likely to "remain closed for some time" while crash investigators examine the scene.• Update 3.30pm: The road reopened earlier this afternoon.
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