South Leicester bounced back from the previous weekend's National Three Midlands defeat to Sandbach by demolishing Derby 59-17.
Gareth Kerr and Will Keeling scored two apiece while Andy Harris, Josh McLaurin, Ricky Aley and Mark Lord also crossed. Lord converted a penalty-try as well as adding four other sets of extras, and Aley kicked two conversions.
Syston lost 49-26 at Sandbach, while Hinckley were edged out 19-16 in an enthralling derby at Nuneaton, despite a try and two conversions from Josh Smith and a score from Devon Constant.
Coalville and Oakham are sitting pretty in the top two of Midlands Two East (North) with four games remaining.
Two more bonus-point wins will all but clinch the title for Coalville after an impressive 39-24 triumph at a fourth-placed Ashbourne outfit that had not previously lost at home.
Tries came from Myles Griffin, Michael Richmond, Matt Twigg, Joe Moretta and Mark Davies. Sam Blackburn kicked two penalties and added four conversions.
Dronfield started the day nine points behind Oakham with a game in hand but they were hammered 55-5 as James Beanland and Angus Boyle notched braces. Rhys Grieve, Mark Matthews, Owen Smith and David Wiggin also crossed, and Matthews kicked 15 points.
The result enabled Oakham to move nine points clear of Belgrave, who suffered an unexpected 28-24 home loss to Nottingham Casuals.
Belgrave's tries came from Louis Summers, Josh Jones and Sean Kyle, while Kev Curtis added nine points with the boot.
Leicester Forest took the derby honours after an emphatic 43-17 win at Aylestone St James.
Dave Lamb (2), Mitch Lamb (2), Liam Warren, Tom Martin and Lee Palmer were Forest's try-scorers, while Callum Dacey and Dean Mooney shared kicking duties.
Jimmies' tries came from Vuz Chinyere, Luke Geary and Jake Harmer, with Jamie Muggleton adding a conversion.
Melton Mowbray won 33-17 at Bakewell Mannerians courtesy of tries from Sean Crowe (2), George Ord, Nick Crossland and Phil Stimson, who also kicked four conversions.
Vipers and Oadby Wyggs are now six points adrift in Midlands Two East (South) with six games to go.
Vipers lost 28-7 to Northampton BBOB while Wyggs suffered a 29-22 setback against Dunstablians.
Wyggs' tries were scored by Bob Beevers (2) and Neil McBride, while Olly Mills kicked two conversions and a penalty.
Luke Cragg scored and Matt Evans converted in Vipers' home match.
Salt was rubbed into Vipers and Wyggs' wounds as Biggleswade beat Lutterworth 20-17 and Wellingborough won against second-placed Leighton Buzzard.
Market Harborough were edged out 13-6 at leaders Huntingdon & District.
