Politicians are set to debate the Government's plans for a high-speed rail link.
Phase two of the £32 billion HS2 project, connecting Birmingham with Leeds, could cut through Leicestershire.
A motion by leader Nick Rushton to a full meeting of Leicestershire County Council on Wednesday will ask members to raise concerns with ministers, MPs and HS2 Ltd.
Councillor Rushton has described the project as "all pain and no gain" for the county.
His motion outlines his concerns, including the potential loss of jobs and road improvements – referring to a Kegworth bypass – and business rates rises if the proposed line blocks the development of the Strategic Rail Freight Interchange at East Midlands Airport.
He highlights the potential blight on other developments along the proposed route, including difficulties it would pose for a solution to congestion at junction 13 of the A42, at Ashby, which Coun Rushton said was a "key requirement for the delivery of growth" in the north west of the county.
The motion also states that Toton is the wrong option for an East Midlands station.
North West Leicestershire District Council's Labour group is supporting the Conservative county council leader's view that Derby would be a better location for the station.
This would mean the line would not have to pass through Leicestershire.
Speaking on behalf of the group, Measham district councillor Tom Neilson said: "Derby City Council has said it wants the East Midlands HS2 station to be in Derby and we agree this is a better option than Toton."
