Hundreds of NHS staff are to be moved to private companies.
Support services and construction group Interserve has been awarded a £300 million contract to run catering, cleaning, maintenance and security services in more than 550 NHS buildings in the county.
About 2,000 workers employed by the NHS are waiting to see if they will be taken on by Interserve.
In a second deal, IBM has taken over the running of information management and technology services for Leicester's hospitals in a move that could affect 88 workers.
The 10-year deal is worth £60 million. It is not yet known if the move will lead to job losses.
Interserve spokesman Maria Kitching, said: "I can't say at this point whether there will be job losses or not.
"But we will be working with the staff to make sure they have the skills to support the NHS in delivering their services."
The contract, which begins at the start of the year, follows a two-year procurement process involving the NHS Leicester City and NHS Leicestershire County and Rutland primary care trusts, the University Hospitals of Leicester NHS Trust and the Leicestershire Partnership NHS Trust.
